Mst1 and Mst2 kinases: regulations and diseases
نویسندگان
چکیده
منابع مشابه
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.
Control of organ size by cell proliferation and survival is a fundamental developmental process, and its deregulation leads to cancer. However, the molecular mechanism underlying organ size control remains elusive in vertebrates. In Drosophila, the Hippo (Hpo) signaling pathway controls organ size by both restricting cell growth and proliferation and promoting cell death. Here we investigated w...
متن کاملThe kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity
Jing Geng1,#, Xiufeng Sun1,#, Ping Wang1, Shihao Zhang1, Xiaozhen Wang1, Hongtan Wu1, Lixin Hong1, Changchuan Xie1, Xun Li2, Hao Zhao1, Qingxu Liu1, Mingting Jiang1, Qinghua Chen1, Jinjia Zhang1, Yang Li1, Siyang Song1, Hong-Rui Wang1, Rongbin Zhou7, Randy L. Johnson5, Kun-Yi Chien3, Sheng-Cai Lin1, Jiahuai Han1, Joseph Avruch4,5, Lanfen Chen1,*, and Dawang Zhou1,* 1State Key Laboratory of Cell...
متن کاملThe tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
The RASSF1A tumor suppressor protein interacts with the pro-apoptotic mammalian STE20-like kinases MST1 and MST2 and induces their autophosphorylation and activation, but the mechanism of how RASSF1A activates MST1/2 is unclear. Okadaic acid treatment and PP2A knockdown promoted MST1/2 phosphorylation. Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A deplet...
متن کاملMOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation
BACKGROUND MST1 and MST2 are the mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapototic; however, little is known concerning the physiologic regulation of the endogenous MST1/MST2 kinases, their role in mammalian cell proliferation,...
متن کاملImpaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2
The liver has an intrinsic capacity to regenerate in response to injury or surgical resection. Nevertheless, circumstances in which hepatocytes are unresponsive to proliferative signals result in impaired regeneration and hepatic failure. As the Hippo pathway has a canonical role in the maintenance of liver size, we investigated whether it could serve as a therapeutic target to support regenera...
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ژورنال
عنوان ژورنال: Cell & Bioscience
سال: 2013
ISSN: 2045-3701
DOI: 10.1186/2045-3701-3-31